Role description

We’re looking for an Applied Translational Scientist (Senior/Principal scientist) to join our team in San Francisco or Boston to work directly with cancer patients and their care teams to translate complex molecular profile data into clear, evidence-based treatment options. This is a non-traditional translational scientist role: you’ll operate at the intersection of oncology, molecular genomics, and clinical evidence interpretation—delivering high-trust guidance that is scientifically rigorous, clinically grounded, and compassionate.

You may come from a variety of backgrounds, but you must have:

• Strong oncology fluency across modalities and tumor types
• A deep understanding of the oncology therapeutic landscape
• Expert ability to interpret clinical trial evidence and apply it to real-world patient contexts
• Exceptional communication skills with patients, clinicians, and scientists across disciplines.

What You’ll Do

• Develop treatment strategies: prioritize SOC, trials, and other options (including off-label/expanded access when appropriate) based on patient molecular data
• Partner with computational biologists to integrate patient molecular data (tissue/liquid; variants, expression, scRNAseq, IHC/mIF as relevant)
• Interpret evidence with rigor: synthesize trial data, biomarker subgroup performance, design limitations, and real-world feasibility; communicate uncertainty transparently.
• Collaborate internally: align with clinical, scientific, and product teams; contribute to interpretation playbooks and evidence summaries.
• Integrate multiple evidence layers—biological plausibility, clinical trial data, guidelines, and patient-specific factors—to form a coherent strategy.
• Contribute to internal knowledge bases: therapy/biomarker evidence summaries, indication briefs, trial digests, and interpretation.

Qualifications

• Advanced degree or equivalent experience in a relevant discipline (with substantial oncology experience), or comparable. Exceptional fit may be considered in the absence of an advanced degree.
• Deep understanding of oncology therapeutics (targeted therapy, immuno-oncology, ADCs, resistance, sequencing, tumor-type nuance).
• Demonstrated strength interpreting clinical trial evidence and explaining clinical relevance (including biomarker subgroups).
• Ability to reason from molecular data to therapy hypotheses while respecting evidence strength, contraindications, and real-world practice patterns.
• Excellent written and verbal communication; ability to present confidently to clinicians and speak clearly with patients.